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Image Search Results
Journal: JCI insight
Article Title: Decidual Cox2 inhibition improves fetal and maternal outcomes in a preeclampsia-like mouse model
doi: 10.1172/jci.insight.75351
Figure Lengend Snippet: (A) Schematic showing experimental strategy used to selectively inhibit Cox2. Celecoxib was administered by oral gavage on E6.5 after implantation but before peak decidualization (E7.5). ( B) Representative Western blot of Cox2, IL-15, and actin in C57 E7.5 and BPH/5 E7.5 implantation sites. (C) Quantification of Cox2 protein and (D) IL-15 protein levels relative to actin in C57 and BPH/5 E7.5 implantation sites after vehicle or celecoxib administration. n = 3 for the vehicle-treated group; n = 4 for the celecoxib-treated group. * P < 0.05 versus vehicle-treated C57 mice and † P < 0.05 versus vehicle-treated BPH/5 mice, by 1-way ANOVA. (E) Representative dot plot of DBA +CD122+-stained cells from BPH/5 E7.5 implantation sites as measured by flow cytometry. Numbers in the boxes reflect the percentage of the total cells recovered that were found to be CD122+DBA-lectin+. (F) Quantitative summary of flow cytometry of DBA +CD122+-stained cells from BPH/5 E7.5 implantation sites for vehicle- ( n = 5) versus celecoxib-treated mice. n = 7. † P < 0.05 versus vehicle-treated BPH/5 mice, by 2-tailed Student’s t test. Data represent the mean ± SEM. dNK, decidual NK; Dpc, days postcoitus; veh, vehicle.
Article Snippet:
Techniques: Western Blot, Staining, Flow Cytometry